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Squamous Cell Carcinoma of the Lung With Microsatellite Instability in a Patient With Lynch Syndrome: A Case Report.

Authors :
Haddad E
Bottet B
Thiebaut PA
Morin S
Dreyfus H
Vannier É
Vincent C
Marguet F
Lamy A
Sobol H
Baste JM
Guisier F
Sabourin JC
Piton N
Source :
JTO clinical and research reports [JTO Clin Res Rep] 2023 Oct 19; Vol. 5 (1), pp. 100595. Date of Electronic Publication: 2023 Oct 19 (Print Publication: 2024).
Publication Year :
2023

Abstract

Lynch syndrome is the most common autosomal dominant inherited cancer predisposing syndrome, due to mutations in DNA mismatch repair genes. The key feature of cancers in Lynch syndrome is microsatellite instability and a high risk of developing mainly colorectal and uterine cancers. However, cancers with microsatellite instability outside this spectrum, for example, lung cancer, are extremely rare. Here, we report a case of squamous cell carcinoma of the lung with microsatellite instability in a patient with Lynch syndrome.<br /> (© 2023 The Authors.)

Details

Language :
English
ISSN :
2666-3643
Volume :
5
Issue :
1
Database :
MEDLINE
Journal :
JTO clinical and research reports
Publication Type :
Report
Accession number :
38229768
Full Text :
https://doi.org/10.1016/j.jtocrr.2023.100595