Back to Search
Start Over
Intra-tumoral T cells in pediatric brain tumors display clonal expansion and effector properties.
- Source :
-
Nature cancer [Nat Cancer] 2024 May; Vol. 5 (5), pp. 791-807. Date of Electronic Publication: 2024 Jan 16. - Publication Year :
- 2024
-
Abstract
- Brain tumors in children are a devastating disease in a high proportion of patients. Owing to inconsistent results in clinical trials in unstratified patients, the role of immunotherapy remains unclear. We performed an in-depth survey of the single-cell transcriptomes and clonal relationship of intra-tumoral T cells from children with brain tumors. Our results demonstrate that a large fraction of T cells in the tumor tissue are clonally expanded with the potential to recognize tumor antigens. Such clonally expanded T cells display enrichment of transcripts linked to effector function, tissue residency, immune checkpoints and signatures of neoantigen-specific T cells and immunotherapy response. We identify neoantigens in pediatric brain tumors and show that neoantigen-specific T cell gene signatures are linked to better survival outcomes. Notably, among the patients in our cohort, we observe substantial heterogeneity in the degree of clonal expansion and magnitude of T cell response. Our findings suggest that characterization of intra-tumoral T cell responses may enable selection of patients for immunotherapy, an approach that requires prospective validation in clinical trials.<br /> (© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.)
- Subjects :
- Humans
Child
Antigens, Neoplasm immunology
Immunotherapy methods
Child, Preschool
Male
Female
Adolescent
Lymphocytes, Tumor-Infiltrating immunology
Single-Cell Analysis methods
Transcriptome
Clone Cells
Brain Neoplasms immunology
Brain Neoplasms pathology
Brain Neoplasms genetics
T-Lymphocytes immunology
Subjects
Details
- Language :
- English
- ISSN :
- 2662-1347
- Volume :
- 5
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Nature cancer
- Publication Type :
- Academic Journal
- Accession number :
- 38228835
- Full Text :
- https://doi.org/10.1038/s43018-023-00706-9