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Hypoxia-Responsive Polymeric Nanoprodrugs for Combo Photodynamic and Chemotherapy.
- Source :
-
ACS omega [ACS Omega] 2023 Dec 22; Vol. 9 (1), pp. 1821-1826. Date of Electronic Publication: 2023 Dec 22 (Print Publication: 2024). - Publication Year :
- 2023
-
Abstract
- Hypoxia in most solid tumors is a major challenge for photodynamic therapy (PDT), and the combination of hypoxia-activated chemotherapy and PDT is a promising approach for enhanced anticancer activity. Herein, we designed hypoxia-responsive polymeric nanoprodrug PNPs to co-deliver photosensitizer 5,10,5,20-tetrakis(4-aminophenyl)-porphine (TAPP) and chlorambucil (CB) to improve the overall therapeutic efficacy. Upon laser irradiation, the central TAPP converted oxygen to produce single oxygen ( <superscript>1</superscript> O <subscript>2</subscript> ) for PDT and induced PDT-reduced hypoxia environment, which accelerated the release of activated CB for synergetic cancer cell killing. Consequently, these hypoxia-responsive polymeric nanoprodrugs with a considerable drug-loading content and synergistic therapeutic effect of PDT-CT had great potential for tumor therapy.<br />Competing Interests: The authors declare no competing financial interest.<br /> (© 2023 The Authors. Published by American Chemical Society.)
Details
- Language :
- English
- ISSN :
- 2470-1343
- Volume :
- 9
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- ACS omega
- Publication Type :
- Academic Journal
- Accession number :
- 38222587
- Full Text :
- https://doi.org/10.1021/acsomega.3c08504