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Impact of pulmonary infection after radical esophagectomy on serum inflammatory markers, pulmonary function indices, and prognosis.
- Source :
-
Saudi medical journal [Saudi Med J] 2024 Jan; Vol. 45 (1), pp. 40-45. - Publication Year :
- 2024
-
Abstract
- Objectives: To analyze the influence of pulmonary infection after radical esophagectomy on serum inflammatory markers, pulmonary function, and prognosis.<br />Methods: We enrolled 278 esophageal cancer patients who underwent radical esophagectomy. Patients were split into the infected (n=51) and uninfected groups (n=227). The inflammatory parameters, complications, and prognosis were compared.<br />Results: In the infected group, interleukin (IL)-6 was 16.19±2.63 ng/L, tumor necrosis factor-α was 19.64±3.07 µg/L, and IL-1β was 22.49±5.13 ng/L at 7 days postoperatively; white blood cell counts was 12.65±2.14 ×10 <superscript>9</superscript> /L, percentage of neutrophils (NEU%) was 67.04±10.48%, and platelet (PLT) counts was 249.82±63.26 ×10 <superscript>9</superscript> /L; the increasing ranges of the above factors after the operation were much raised compared with the uninfected group ( p <0.05). Compared with the uninfected group, forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and FEV1/FVC were greater declines in ranges ( p <0.05), and the arrhythmia incidence and the mortality within 60 days postoperatively were greater in the infected group ( p <0.05).<br />Conclusion: Postoperative pulmonary infection can lead to pulmonary function damage, proinflammatory factor overexpression, and an increased risk of early death.<br /> (Copyright: © Saudi Medical Journal.)
Details
- Language :
- English
- ISSN :
- 1658-3175
- Volume :
- 45
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Saudi medical journal
- Publication Type :
- Academic Journal
- Accession number :
- 38220231
- Full Text :
- https://doi.org/10.15537/smj.2024.45.1.20230504