Chitosan/PEG-mediated spinal cord fusion after complete dorsal transection in rabbits - functional results at 30 days.

Authors :: Lebenstein-Gumovski M
Rasueva T
Zharchenko A
Bashahanov R
Kovalev DA
Zhirov A
Shatokhin A
Grin A
Source :: Surgical neurology international [Surg Neurol Int] 2023 Dec 13; Vol. 14, pp. 423. Date of Electronic Publication: 2023 Dec 13 (Print Publication: 2023).
Publication Year :: 2023
Abstract: Background: The aim was to study functional recovery in experimental animals (rabbits) with transected spinal cords treated with a combination of photo-cross-linked chitosan in a homogeneous mixture with polyethylene glycol (PEG-chitosan). Methods: 20 rabbits ( n = 10 experimental and n = 10 controls) were submitted to complete spinal cord transection at T9. The experimental group received an intraoperative injection of PEG-chitosan. Neurological recovery was assessed using the modified Basso, Beattie, and Bresnahan scale. Results: In the experimental group, partial recovery of movements, sensory function, and sphincter control were all observed by postoperative day 30. Paraplegia and anesthesia persisted in the control group; 4 controls died versus none in the test group. Conclusion: PEG-chitosan is a candidate for neurological restoration after spinal paralysis. Competing Interests: There are no conflicts of interest. (Copyright: © 2023 Surgical Neurology International.)

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