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Tumor iron homeostasis and immune regulation.
- Source :
-
Trends in pharmacological sciences [Trends Pharmacol Sci] 2024 Feb; Vol. 45 (2), pp. 145-156. Date of Electronic Publication: 2024 Jan 11. - Publication Year :
- 2024
-
Abstract
- Abnormal iron metabolism has long been regarded as a key metabolic hallmark of cancer. As a critical cofactor, iron contributes to tumor progression by participating in various processes such as mitochondrial electron transport, gene regulation, and DNA synthesis or repair. Although the role of iron in tumor cells has been widely studied, recent studies have uncovered the interplay of iron metabolism between tumor cells and immune cells, which may affect both innate and adaptive immune responses. In this review, we discuss the current understanding of the regulatory networks of iron metabolism between cancer cells and immune cells and how they contribute to antitumor immunity, and we analyze potential therapeutics targeting iron metabolism. Also, we highlight several key challenges and describe potential therapeutic approaches for future investigations.<br />Competing Interests: Declaration of interests The authors declare no competing interests.<br /> (Copyright © 2023 Elsevier Ltd. All rights reserved.)
- Subjects :
- Humans
Iron metabolism
Homeostasis
Immunity, Innate
Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3735
- Volume :
- 45
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Trends in pharmacological sciences
- Publication Type :
- Academic Journal
- Accession number :
- 38212195
- Full Text :
- https://doi.org/10.1016/j.tips.2023.12.003