The sound of silent RNA in tuberculosis and the lncRNA role on infection.

Authors :: Rocha EF
Vinhaes CL
Araújo-Pereira M
Mota TF
Gupte AN
Kumar NP
Arriaga MB
Sterling TR
Babu S
Gaikwad S
Karyakarte R
Mave V
Kulkarni V
Paradkar M
Viswanathan V
Kornfeld H
Gupta A
Andrade BB
Queiroz ATL
Source :: IScience [iScience] 2023 Dec 08; Vol. 27 (1), pp. 108662. Date of Electronic Publication: 2023 Dec 08 (Print Publication: 2024).
Publication Year :: 2023
Abstract: Tuberculosis (TB) is one of the leading causes of death worldwide, and Diabetes Mellitus is one of the major comorbidities (TB/DM) associated with the disease. A total of 103 differentially expressed ncRNAs have been identified in the TB and TB/DM comparisons. A machine learning algorithm was employed to identify the most informative lncRNAs: ADM-DT, LINC02009, LINC02471, SOX2-OT, and GK-AS1. These lncRNAs presented substantial accuracy in classifying TB from HC (AUCs >0.85) and TB/DM from HC (AUCs >0.90) in the other three countries. Genes with significant correlations with the five lncRNAs enriched common pathways in Brazil and India for both TB and TB/DM. This suggests that lncRNAs play an important role in the regulation of genes related to the TB immune response.<br />Competing Interests: The authors declare no competing interests.<br /> (© 2023 The Authors.)