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Preparation of PMMA-Based Temperature/pH Responsive Nanoparticles Encapsulating 5-Fluorouracil and Methotrexate In Situ by One-Pot Dispersion Photopolymerization.
- Source :
-
Macromolecular bioscience [Macromol Biosci] 2024 May; Vol. 24 (5), pp. e2300469. Date of Electronic Publication: 2024 Jan 12. - Publication Year :
- 2024
-
Abstract
- In order to achieve long-term and controllable release of anti-tumor drugs at specific sites, temperature/pH responsive nanoparticles encapsulating 5-fluorouracil and methotrexate in situ are prepared through dispersion photopolymerization under green LED irradiation. The physicochemical properties of nanoparticles are characterized by scanning electron microscopy, Fourier transform infrared, dynamic light scattering, thermogravimetric/differential scanning calorimetry, and X-ray diffraction. In vitro drug release at different temperatures and pH values is examined to ascertain the release pattern of two drugs, which can be well described by Korsmeyer-Peppas kinetic model. The cytotoxicity evaluation illustrates that the tumor cells could be more effectively killed by the drug-loaded nanoparticles, and the improved therapeutic effect is attributed to the controllable and sustainable drug release as well as the enhanced cellular uptake. The blood safety and good biocompatibility of nanoparticles are further confirmed by hemolysis assay, indicating the prepared nanoparticles are potential candidates for effective tumor treatment.<br /> (© 2024 Wiley‐VCH GmbH.)
- Subjects :
- Hydrogen-Ion Concentration
Humans
Polymerization
Hemolysis drug effects
Drug Liberation
Drug Carriers chemistry
Animals
X-Ray Diffraction
Antimetabolites, Antineoplastic pharmacology
Antimetabolites, Antineoplastic chemistry
Cell Line, Tumor
Fluorouracil pharmacology
Fluorouracil chemistry
Methotrexate pharmacology
Methotrexate chemistry
Nanoparticles chemistry
Temperature
Polymethyl Methacrylate chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1616-5195
- Volume :
- 24
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Macromolecular bioscience
- Publication Type :
- Academic Journal
- Accession number :
- 38197551
- Full Text :
- https://doi.org/10.1002/mabi.202300469