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GZMK+CD8+ T cells Target A Specific Acinar Cell Type in Sjögren's Disease.
- Source :
-
Research square [Res Sq] 2024 Jul 11. Date of Electronic Publication: 2024 Jul 11. - Publication Year :
- 2024
-
Abstract
- Sjögren's Disease (SjD) is a systemic autoimmune disease without a clear etiology or effective therapy. Utilizing unbiased single-cell and spatial transcriptomics to analyze human minor salivary glands in health and disease we developed a comprehensive understanding of the cellular landscape of healthy salivary glands and how that landscape changes in SjD patients. We identified novel seromucous acinar cell types and identified a population of PRR4+CST3+WFDC2 - seromucous acinar cells that are particularly targeted in SjD. Notably, GZMK +CD8 T cells, enriched in SjD, exhibited a cytotoxic phenotype and were physically associated with immune-engaged epithelial cells in disease. These findings shed light on the immune response's impact on transitioning acinar cells with high levels of secretion and explain the loss of this specific cell population in SjD. This study explores the complex interplay of varied cell types in the salivary glands and their role in the pathology of Sjögren's Disease.
Details
- Language :
- English
- ISSN :
- 2693-5015
- Database :
- MEDLINE
- Journal :
- Research square
- Publication Type :
- Academic Journal
- Accession number :
- 38196575
- Full Text :
- https://doi.org/10.21203/rs.3.rs-3601404/v2