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Unlocking translational machinery for antitubercular drug development.
- Source :
-
Trends in biochemical sciences [Trends Biochem Sci] 2024 Mar; Vol. 49 (3), pp. 195-198. Date of Electronic Publication: 2024 Jan 08. - Publication Year :
- 2024
-
Abstract
- Targeting translational factor proteins (TFPs) presents significant promise for the development of innovative antitubercular drugs. Previous insights from antibiotic binding mechanisms and recently solved 3D crystal structures of Mycobacterium tuberculosis (Mtb) elongation factor thermo unstable-GDP (EF-Tu-GDP), elongation factor thermo stable-EF-Tu (EF-Ts-EF-Tu), and elongation factor G-GDP (EF-G-GDP) have opened up new avenues for the design and development of potent antituberculosis (anti-TB) therapies.<br />Competing Interests: Declaration of interests No interests are declared.<br /> (Copyright © 2023 Elsevier Ltd. All rights reserved.)
- Subjects :
- Guanosine Diphosphate chemistry
Guanosine Diphosphate metabolism
Peptide Elongation Factors chemistry
Peptide Elongation Factors metabolism
Proteins metabolism
Peptide Elongation Factor Tu chemistry
Peptide Elongation Factor Tu metabolism
Antitubercular Agents pharmacology
Antitubercular Agents therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 0968-0004
- Volume :
- 49
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Trends in biochemical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 38195289
- Full Text :
- https://doi.org/10.1016/j.tibs.2023.12.008