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Gut microbiome diversity in a febrile seizure mouse model.

Authors :
Kim Y
Jang Y
Shin YW
Jeon D
Yoo JS
Park DK
Lee HS
Ahn SJ
Park KI
Jung KH
Lee ST
Lee SK
Chu K
Source :
Encephalitis (Seoul, Korea) [Encephalitis] 2024 Jan; Vol. 4 (1), pp. 11-17. Date of Electronic Publication: 2024 Jan 10.
Publication Year :
2024

Abstract

Purpose: Febrile seizures at a young age can provoke late-onset temporal lobe epilepsy. Since recent evidence has suggested that the gut microbiome affects central nervous system pathology across the blood-brain barrier, we hypothesized that febrile seizures alter the composition of the gut microbiome to provoke epilepsy.<br />Methods: Third-generation C57BL/6 mice were separated into two groups (n = 5 each), and hot air was applied to only one group to cause febrile seizures. After two weeks of heat challenge, the fecal pellets acquired from each group were analyzed.<br />Results: The gut microbiota of fecal pellets from each group revealed five taxa at the genus level and eight taxa at the species level that were significantly different in proportion between the groups.<br />Conclusion: Although there was no significant difference in the overall diversity of the gut microbiota between the two groups, the identified heterogeneity may imply the pathognomonic causative relevance of febrile seizures and the development of epilepsy.

Details

Language :
English
ISSN :
2734-1461
Volume :
4
Issue :
1
Database :
MEDLINE
Journal :
Encephalitis (Seoul, Korea)
Publication Type :
Academic Journal
Accession number :
38195066
Full Text :
https://doi.org/10.47936/encephalitis.2023.00206