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Risk of Neuropsychiatric Symptoms Among People Who Develop Cognitive Impairment With and Without a History of Post-traumatic Stress Disorder.
- Source :
-
Alzheimer disease and associated disorders [Alzheimer Dis Assoc Disord] 2024 Jan-Mar 01; Vol. 38 (1), pp. 91-94. Date of Electronic Publication: 2023 Dec 28. - Publication Year :
- 2024
-
Abstract
- We aimed to prospectively assess the change in neuropsychiatric symptoms among people who develop cognitive impairment and have a history of post-traumatic stress disorder (PTSD). We analyzed longitudinal data from the National Alzheimer's Coordinating Center Unified Data Set (March 2015 to December 2021). Analyses included individuals who were cognitively normal and who had nonmissing assessment of PTSD at the initial visit and had at least 1 follow-up visit with cognitive impairment. We compared the difference in the mean neuropsychiatric symptom score at the first Unified Data Set visit versus the first visit with a Clinical Dementia Rating of 0.5 between those with and without a history of PTSD. The mean neuropsychiatric symptom score change did not differ between those with and without a history of PTSD (1.06 vs. 0.77, respectively; P =0.79). The null results found in this study warrant future research. Several methodological limitations might explain these results.<br />Competing Interests: J.P.P. and his institution are currently receiving grants from the NIH (K01MD014177, R21AG065755, and P30 AG035982). O.L.M. and her institution are currently receiving grants from the NIH (R01AG067541 and P30AG072972). W.A.K. and his institution are currently receiving grants from the NIH, principally U24 AG072122. The remaining authors declare no conflicts of interest.<br /> (Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.)
- Subjects :
- Humans
Stress Disorders, Post-Traumatic diagnosis
Cognitive Dysfunction psychology
Subjects
Details
- Language :
- English
- ISSN :
- 1546-4156
- Volume :
- 38
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Alzheimer disease and associated disorders
- Publication Type :
- Academic Journal
- Accession number :
- 38194584
- Full Text :
- https://doi.org/10.1097/WAD.0000000000000594