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The effect of oxygen supply using perfluorocarbon-based nanoemulsions on human hair growth.
- Source :
-
Journal of materials chemistry. B [J Mater Chem B] 2024 Jan 24; Vol. 12 (4), pp. 991-1000. Date of Electronic Publication: 2024 Jan 24. - Publication Year :
- 2024
-
Abstract
- Hair dermal papilla cells (hDPCs) play a crucial role in hair growth and regeneration, and their function is influenced by nutrient and oxygen supply. A microenvironment with significantly low oxygen (O <subscript>2</subscript> ) levels, known as anoxic conditions (<0.2%) due to oxygen deficiency, hinders hDPC promotion and retards hair regrowth. Here, a nanoemulsion (NE) based on perfluorooctyl bromide (PFOB), a member of the perfluorocarbon family, is presented to provide a sustainable O <subscript>2</subscript> supply and maintain physical stability in vitro . The PFOB-NE has been shown to continuously release oxygen for 36 h, increasing and maintaining the O <subscript>2</subscript> concentration in the anoxic microenvironment of up to 0.8%. This sustainable O <subscript>2</subscript> supply using PFOB-NE has promoted hDPC growth and also induced a complex cascade of effects. These effects encompass regulation via inhibiting lactate accumulation caused via oxygen deficiency, increasing lactate dehydrogenase activity, and promoting the expression of genes, such as the hypoxia-inducible factor 1 family and NADPH oxidase 4 under anoxic conditions. Sustained O <subscript>2</subscript> supply is shown to enhance human hair organ elongation approximately four times compared to the control under anoxic conditions. In conclusion, the perfluorocarbon-based NE containing oxygen proves to be an important strategic tool for improving hair growth and alleviating hair loss.
Details
- Language :
- English
- ISSN :
- 2050-7518
- Volume :
- 12
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of materials chemistry. B
- Publication Type :
- Academic Journal
- Accession number :
- 38193597
- Full Text :
- https://doi.org/10.1039/d3tb02237d