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Combined exposure to lead and microplastics increased risk of glucose metabolism in mice via the Nrf2/NF-κB pathway.
- Source :
-
Environmental toxicology [Environ Toxicol] 2024 May; Vol. 39 (5), pp. 2502-2511. Date of Electronic Publication: 2024 Jan 05. - Publication Year :
- 2024
-
Abstract
- The purpose of this study was to explore the effects of combined lead (Pb) and two types of microplastic (MP) (polyvinyl chloride [PVC] and polyethylene [PE]) exposure on glucose metabolism and investigate the role of the nuclear factor erythroid 2-related factor 2 (Nrf2)/nuclear factor-kappa B (NF-κB) signaling pathway in mediating these effects in mice. Adult C57BL/6J mice were randomly divided into four groups: control, Pb (100 mg/L), MPs (containing 10 mg/L PE and PVC), and Pb + MPs, each of which was treated with drinking water. Treatments were conducted for 6 weeks. Co-exposure to Pb + MPs exhibited increase glycosylated serum protein levels, insulin resistance, and damaged glucose tolerance compared with the control mice. Additionally, treatment with Pb + MPs caused more severe damage to hepatocytes than when exposed to them alone concomitantly, exposed to Pb + MPs exhibited improved the levels of interleukin-6, tumor necrosis factor-alpha, and malondialdehyde, but reduced superoxide dismutase, glutathione peroxidase, and catalase assay in livers. Furthermore, they increase the Kelch-like ECH-associated protein 1 (Keap1) and phosphorylated p-NF-κB protein levels but reduced the protein levels of heme oxygenase-1 and Nrf2, as well as increased Keap1 mRNA and Nrf2 mRNA. Co-exposure to Pb + MP impacts glucose metabolism via the Nrf2 /NF-κB pathway.<br /> (© 2024 Wiley Periodicals LLC.)
- Subjects :
- Mice
Animals
Kelch-Like ECH-Associated Protein 1 genetics
Kelch-Like ECH-Associated Protein 1 metabolism
NF-E2-Related Factor 2 genetics
NF-E2-Related Factor 2 metabolism
Microplastics
Lead
Mice, Inbred C57BL
Oxidative Stress
RNA, Messenger metabolism
Glucose pharmacology
NF-kappa B metabolism
Plastics metabolism
Plastics pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1522-7278
- Volume :
- 39
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Environmental toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 38180308
- Full Text :
- https://doi.org/10.1002/tox.24125