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Clinical characteristics and treatment modalities in uremic and non uremic calciphylaxis - a dermatological single-center experience.
- Source :
-
Renal failure [Ren Fail] 2024 Dec; Vol. 46 (1), pp. 2297566. Date of Electronic Publication: 2024 Jan 04. - Publication Year :
- 2024
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Abstract
- Calciphylaxis (CP) is a serious, potentially life-threatening disease that presents with medial calcification of small-sized vessels and painful ischemic ulcerations. Although calciphylaxis is frequently seen in patients with end-stage kidney disease on dialysis (calcific uremic arteriolopathy, CUA), there are reported cases of nonuremic calciphylaxis (NUC), which often remain undiagnosed. We conducted a retrospective chart review at our dermatological hospital and evaluated data concerning the epidemiology, comorbidities, medication, laboratory abnormalities, and therapeutic approaches of 60 patients diagnosed with calciphylaxis between 01/2012 and 12/2022. We identified 21 patients diagnosed with NUC and 39 with kidney disease. The predilection sites of skin lesions were the lower legs in 88% ( n = 53), followed by the thigh and gluteal regions in 7% ( n = 4). Significant differences were identified in comorbidities, such as atrial fibrillation ( p < 0.001) and hyperparathyroidism ( p < 0.01) accounting for CUA patients. Medication with vitamin K antagonists ( p < 0.001) , phosphate binders ( p < 0.001 ), and loop diuretics ( p < 0.01 ) was found to be associated with the onset of calciphylaxis. Hyperphosphatemia ( p < 0.001 ), increased parathyroid hormone ( p < 0.01 ) and triglyceride levels ( p < 0.01) , hypoalbuminemia ( p < 0.01) and decreased hemoglobin values ( p < 0.001) in the CUA cohort were significantly different from those in the NUC group. All patients with CUA received systemic medication. In contrast, only 38% ( n = 8) of patients with NUC received systemic treatment. Striking discrepancies in the treatment of both cohorts were detected. In particular, NUC remains a disease pattern that is still poorly understood and differs from CUA in several important parameters.
Details
- Language :
- English
- ISSN :
- 1525-6049
- Volume :
- 46
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Renal failure
- Publication Type :
- Academic Journal
- Accession number :
- 38178572
- Full Text :
- https://doi.org/10.1080/0886022X.2023.2297566