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Biological recognition and cellular trafficking of targeted RNA-lipid nanoparticles.

Authors :
Escalona-Rayo O
Papadopoulou P
Slütter B
Kros A
Source :
Current opinion in biotechnology [Curr Opin Biotechnol] 2024 Feb; Vol. 85, pp. 103041. Date of Electronic Publication: 2023 Dec 27.
Publication Year :
2024

Abstract

Lipid nanoparticles (LNPs) have unlocked the potential of ribonucleic acid (RNA) therapeutics and vaccines. Production and large-scale manufacturing methods for RNA-LNPs have been established and rapidly accelerate. Despite this, basic research on LNPs is still required, due to their high assembly complexity and fairly new development, including research on lipid organization, transfection optimization, and in vivo behavior. Understanding fundamental aspects of LNPs that is, how lipid composition and physicochemical properties affect their biodistribution, cell recognition, and transfection, could propel their clinical development and facilitate overcoming current challenges. Herein, we review recent developments in the field of LNP technology and summarize the main findings focusing on nano-bio interactions.<br />Competing Interests: Declaration of Competing Interest I hereby confirm that there is no conflict of interest regarding the paper.<br /> (Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.)

Details

Language :
English
ISSN :
1879-0429
Volume :
85
Database :
MEDLINE
Journal :
Current opinion in biotechnology
Publication Type :
Academic Journal
Accession number :
38154322
Full Text :
https://doi.org/10.1016/j.copbio.2023.103041