Influence of left ventricular ejection fraction in patients undergoing contemporary pLVAD-supported high-risk PCI.

Background: Left ventricular (LV) systolic dysfunction worsens outcomes in patients undergoing percutaneous coronary intervention (PCI). The objective of this study, therefore, was to evaluate outcomes of pLVAD-supported high-risk PCI (HRPCI) patients according to LV ejection fraction (LVEF).
Methods: Patients from the PROTECT III study undergoing pLVAD-supported HRPCI were stratified according to baseline LVEF: severe LV dysfunction (LVEF <30%), mild and moderate LV dysfunction (LVEF ≥30% to <50%), or preserved LV function (LVEF ≥50%). Major adverse cardiovascular and cerebrovascular events (MACCE: composite of all-cause death, myocardial infarction, stroke/transient ischemic attack, and repeat revascularization), and PCI-related complications were assessed at 90 days and mortality was assessed at 1-year.
Results: From March 2017 to March 2020, 940 patients had evaluable baseline LVEF recorded in the study database. Patients with preserved LV function were older, more frequently presented with myocardial infarction, and underwent more left main PCI and atherectomy. Immediate PCI-related coronary complications were infrequent (2.7%, overall), similar between groups (P = 0.98), and not associated with LVEF. Unadjusted 90-day MACCE rates were similar among LVEF groups; however, as a continuous variable, LVEF was associated with both 90-day MACCE (adj.HR per 5% 0.89, 95% CI [0.80, 0.98], P = 0.018) and 1-year mortality (adj.HR per 5% 0.84 [0.78, 0.90], P <0.0001).
Conclusions: Patients who underwent pLVAD-supported HRPCI exhibited low incidence of PCI-related complications, regardless of baseline LVEF. However, LVEF was associated with 90-day MACCE and 1-year mortality.
Competing Interests: Disclosures C.L. Grines reports participation on the advisory boards for Philips and Abiomed. W.B. Batchelor reports consulting for Abbott, Medtronic, Abiomed, and Boston Scientific. A.S. Bharadwaj has received consultant and speaker fees from Abiomed Inc, Cardiovascular Systems Inc and Shockwave Medical. J.W. Moses reports holding equity in Orchestra Biomed. A.G. Truesdell has received consultant and speaker fees from Abiomed, Inc. and Shockwave Medical Inc. S.J. Baron reports receiving consulting fees from Abbott, Abiomed, Edwards LifeSciences, and MitraLabs outside the submitted work as well as speaker fees from and advisory board membership with Boston Scientific. A.J. Lansky received speaker fees from Keystone Heart. M.B. Basir reports consultant fees from Abbott Vascular, Abiomed, Cardiovascular Systems, Chiesi, and Zoll. D.J. Cohen reports grant funding and consulting income from Edwards LifeSciences, Medtronic, Abbott, Boston Scientific, Philips, and CathWorks. W.W. O'Neill reports grant/research support from St. Jude Medical, Edwards Life Sciences, and Biomed; consulting fees/honoraria from Medtronic and Abiomed; and major stock shareholder/equity in Synecor, Accumed, Neovasc, Tendyne, and Mitral Align. The remaining authors report no relevant conflicts of interest.
(Copyright © 2023. Published by Elsevier Inc.)