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Reactive Oxygen Species Scavenging Nanozymes: Emerging Therapeutics for Acute Liver Injury Alleviation.
- Source :
-
International journal of nanomedicine [Int J Nanomedicine] 2023 Dec 22; Vol. 18, pp. 7901-7922. Date of Electronic Publication: 2023 Dec 22 (Print Publication: 2023). - Publication Year :
- 2023
-
Abstract
- Acute liver injury (AIL), a fatal clinical disease featured with a swift deterioration of hepatocyte functions in the short term, has emerged as a serious public health issues that warrants attention. However, the effectiveness of existing small molecular antioxidants and anti-inflammatory medications in alleviating AIL remains uncertain. The unique inherent structural characteristics of liver confer it a natural propensity for nanoparticle capture, which present an opportunity to exploit in the formulation of nanoscale therapeutic agents, enabling their selective accumulation in the liver and thereby facilitating targeted therapeutic interventions. Significantly increased reactive oxygen species (ROS) accumulation and inflammation response have been evidenced to play crucial roles in occurrence and development of AIL. Nanozymes with ROS-scavenging capacities have demonstrated considerable promise in ROS elimination and inflammation regulation, thereby offering an appealing therapeutic instrument for the management of acute liver injury. In this review, the mechanisms of different type of ALI were summarized. In addition, we provide a comprehensive summary and review of the available ROS-scavenging nanozymes, including transition metal-based nanozymes, noble metal nanozymes, carbon-based nanozymes, and some other nanozymes. Furthermore, the challenges still need to be solved in the field of ROS-scavenging nanozymes for ALI alleviation are also discussed.<br />Competing Interests: The authors report no conflicts of interest in this work.<br /> (© 2023 Sun et al.)
- Subjects :
- Humans
Reactive Oxygen Species
Inflammation
Antioxidants
Liver
Hepatocytes
Subjects
Details
- Language :
- English
- ISSN :
- 1178-2013
- Volume :
- 18
- Database :
- MEDLINE
- Journal :
- International journal of nanomedicine
- Publication Type :
- Academic Journal
- Accession number :
- 38148856
- Full Text :
- https://doi.org/10.2147/IJN.S435544