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Ultrastructural Details of Epiretinal Membrane Foveoschisis.
- Source :
-
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde [Ophthalmologica] 2024; Vol. 247 (2), pp. 85-94. Date of Electronic Publication: 2023 Dec 23. - Publication Year :
- 2024
-
Abstract
- Introduction: The aim of this study was to describe differences in the vitreomacular interface (VMI) in idiopathic epiretinal membrane (ERM) foveoschisis compared to macular pseudohole (MPH) and lamellar macular hole (LMH).<br />Methods: We analysed surgically excised epiretinal material and internal limiting membrane (ILM) specimens obtained from 16 eyes of 16 patients with ERM foveoschisis (6 eyes), MPH (5 eyes), and LMH (5 eyes) during standard pars plana vitrectomy (PPV) with membrane peeling. The three entities were classified according to the newly introduced optical coherence tomography (OCT) terminology. Transmission electron microscopy (TEM) was used to describe the ultrastructural features.<br />Results: We found fibrocellular epiretinal tissues in all samples analysed. However, the cell and collagen composition of the VMI differed between groups. Eyes with ERM foveoschisis were characterized by a higher number of cells, multilayered membranes, and thick strands of vitreous collagen embedding the major cell types of myofibroblasts compared to MPH. Eyes with MPH also showed a predominance of myofibroblasts, but these were located directly on the ILM with no collagen between the cells and the ILM. Eyes with LMH showed a thick, multilayered epiretinal proliferation consisting mainly of non-tractional glial cells, corresponding to hypodense epiretinal proliferation on OCT. Eyes with ERM foveoschisis and MPH were more likely to have incomplete PVD compared to LMH in terms of posterior hyaloid status.<br />Discussion/conclusion: Tractional ERMs in eyes with ERM foveoschisis and MPH differ in their ultrastructure. The main difference is in the amount and topographical distribution of vitreous collagen. However, the epiretinal cell types are predominantly myofibroblasts in both entities. This highlights the importance of distinguishing ERM foveoschisis from both MPH and LMH in terms of pathogenesis and surgical peeling procedures.<br /> (© 2023 S. Karger AG, Basel.)
- Subjects :
- Humans
Female
Male
Aged
Middle Aged
Basement Membrane ultrastructure
Retrospective Studies
Aged, 80 and over
Vitreous Body ultrastructure
Vitreous Body pathology
Epiretinal Membrane diagnosis
Epiretinal Membrane surgery
Tomography, Optical Coherence methods
Retinoschisis diagnosis
Vitrectomy methods
Microscopy, Electron, Transmission
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0267
- Volume :
- 247
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde
- Publication Type :
- Academic Journal
- Accession number :
- 38142686
- Full Text :
- https://doi.org/10.1159/000535539