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Development of cassava starch-based films incorporated with phenolic compounds produced by an Amazonian fungus.

Development of cassava starch-based films incorporated with phenolic compounds produced by an Amazonian fungus.

Authors :
Falcão LS
Oliveira IL
Gurgel RS
de Souza ATF
Mendonça LS
Usuda ÉO
do Amaral TS
Veggi PC
Campelo PH
de Vasconcellos MC
Albuquerque PM
de Moraes MA
Source :
International journal of biological macromolecules [Int J Biol Macromol] 2024 Feb; Vol. 258 (Pt 1), pp. 128882. Date of Electronic Publication: 2023 Dec 21.
Publication Year :
2024

Abstract

Drug-release systems have attracted attention over the last few years since they can be used as a substitute for traditional methods of drug delivery. These have the advantage of being directly administered at the treatment site and can maintain the drug at adequate levels for a longer period, thus increasing their efficacy. Starch-based films are interesting candidates for use as matrices for drug release, especially due to starch's non-toxic properties and its biocompatibility. Endophytic fungi are an important source of bioactive molecules, including secondary metabolites such as phenolic compounds with antioxidant activity. In the present study, cassava starch-based films were developed to act as release systems of phenolic compounds with antioxidant activity. The Amazonian endophytic fungus Aspergillus niger MgF2 was cultivated in liquid media, and the fungal extract was obtained by liquid-liquid partition with ethyl acetate. The starch-based films incorporated with the fungal extract were characterized in regards to their physicochemical properties. The release kinetics of the extract from the film and its antioxidant and cytotoxic properties were also evaluated. The films incorporated with the extract presented maximum release after 25 min at 37 °C and pH 6.8. In addition, it was observed that the antioxidant compounds of the fungal extract maintain their activity after being released from the film, and were non-toxic. Therefore, considering the promising physicochemical properties of the extract-incorporated films, and their considerable antioxidant capacity, the films demonstrate great biotechnological potential with diverse applications in the pharmacological and cosmetic industries.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2023 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1879-0003
Volume :
258
Issue :
Pt 1
Database :
MEDLINE
Journal :
International journal of biological macromolecules
Publication Type :
Academic Journal
Accession number :
38141712
Full Text :
https://doi.org/10.1016/j.ijbiomac.2023.128882