Temporary HMCES-DNA cross-link prevents permanent DNA damage.

Authors :: Ruiz PD
Smogorzewska A
Source :: Cell reports [Cell Rep] 2024 Jan 23; Vol. 43 (1), pp. 113594. Date of Electronic Publication: 2023 Dec 22.
Publication Year :: 2024
Abstract: HMCES, a recently discovered but ancient protein, covalently attaches to damaged single-stranded DNA and shields it from nucleases. Rua-Fernandez and colleagues now show that HMCES catalyzes its own recycling, permitting normal growth and non-mutagenic DNA repair. <superscript>1</superscript> .<br />Competing Interests: Declaration of interests A.S. consults for Rocket Pharmaceuticals.<br /> (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)