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Comparison of EULAR/PRINTO/PReS Ankara 2008 and 2022 ACR/EULAR classification criteria for granulomatosis with polyangiitis in children.
- Source :
-
Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2024 Sep 01; Vol. 63 (SI2), pp. SI122-SI128. - Publication Year :
- 2024
-
Abstract
- Objective: Granulomatosis with polyangiitis (GPA) is an ANCA-associated vasculitis. The 2022 ACR/EULAR-endorsed classification criteria for GPA was derived using data only from adult patients. We aimed to assess the performance of the ACR/EULAR classification criteria for GPA in paediatric patients and compare it with the EULAR/Pediatric Rheumatology International Trials Organization (PRINTO)/Pediatric Rheumatology European Society (PReS)-endorsed Ankara 2008 criteria for GPA.<br />Methods: Retrospective data of paediatric patients with GPA in 20 centres from 9 countries were evaluated. The diagnosis of GPA was made according to the expert opinion. The sensitivity, specificity, positive predictive value, and negative predictive value of the criteria sets were evaluated.<br />Results: The study included 77 patients with GPA and 108 controls [IgA vasculitis (n = 44), Takayasu's arteritis (n = 20), microscopic polyangiitis (n = 16), polyarteritis nodosa (n = 14), Behçet's disease (n = 12), eosinophilic granulomatosis with polyangiitis (n = 1) and Cogan's syndrome (n = 1)] with a median age of 17.8 and 15.2 years, respectively. Among patients with GPA, constitutional symptoms (85.7%) and ENT involvement (79.2%) were the most common presentations. In the GPA group, 73 patients fulfilled the Ankara 2008 criteria and 69 the ACR/EULAR classification criteria. Sensitivities of the Ankara 2008 criteria and the ACR/EULAR classification criteria were 94.8% and 89.6%, while specificities were 95.3% and 96.3%, respectively. No significant difference was found between sensitivities and specificities of both classification criteria (P = 0.229 and P = 0.733, respectively).<br />Conclusion: In children, both the ACR/EULAR and EULAR/PRINTO/PReS Ankara 2008 classification criteria for GPA perform well and similarly.<br /> (© Crown copyright 2023.)
- Subjects :
- Humans
Child
Female
Male
Retrospective Studies
Adolescent
Microscopic Polyangiitis classification
Microscopic Polyangiitis diagnosis
Child, Preschool
Rheumatology standards
Polyarteritis Nodosa classification
Polyarteritis Nodosa diagnosis
Behcet Syndrome classification
Behcet Syndrome diagnosis
IgA Vasculitis diagnosis
IgA Vasculitis classification
Churg-Strauss Syndrome diagnosis
Churg-Strauss Syndrome classification
Predictive Value of Tests
Europe
Granulomatosis with Polyangiitis classification
Granulomatosis with Polyangiitis diagnosis
Takayasu Arteritis classification
Takayasu Arteritis diagnosis
Sensitivity and Specificity
Subjects
Details
- Language :
- English
- ISSN :
- 1462-0332
- Volume :
- 63
- Issue :
- SI2
- Database :
- MEDLINE
- Journal :
- Rheumatology (Oxford, England)
- Publication Type :
- Academic Journal
- Accession number :
- 38135503
- Full Text :
- https://doi.org/10.1093/rheumatology/kead693