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S-1 maintenance therapy in advanced gastric cancer without disease progression after first-line chemotherapy: A retrospective analysis.
- Source :
-
Science progress [Sci Prog] 2023 Oct-Dec; Vol. 106 (4), pp. 368504231212792. - Publication Year :
- 2023
-
Abstract
- For patients with advanced gastric cancer after chemotherapy, the optimal mode of maintenance therapy is not yet clear. This research aimed to compare the efficacy and adverse effects of S-1 maintenance therapy and follow-up observation in patients with advanced gastric cancer without disease progression after first-line combined chemotherapy. This study retrospectively analyzed 106 patients from January 2018 to December 2021. The primary endpoints were overall survival and progression-free survival, the secondary endpoint was chemotherapy-related toxicity, and the curative effects and baseline characteristics of the patients were analyzed. Longer progression-free survival and overall survival were observed in the S-1 maintenance treatment group than in the follow-up observation group ( p < 0.001). No obvious differences existed in the subgroup results regarding progression-free survival or overall survival ( p > 0.05). In the maintenance treatment group, the occurrence of thrombocytopenia and hand-foot syndrome was significantly increased ( p < 0.001). No toxicity-related deaths occurred. The included patients without disease progression after first-line combined chemotherapy can achieve significant survival benefits by receiving S-1 maintenance therapy. The patient's tolerance to S-1 maintenance therapy was good.<br />Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
- Subjects :
- Humans
Retrospective Studies
Disease Progression
Stomach Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2047-7163
- Volume :
- 106
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Science progress
- Publication Type :
- Academic Journal
- Accession number :
- 38130176
- Full Text :
- https://doi.org/10.1177/00368504231212792