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Bifidobacterium breve M-16V regulates the autonomic nervous system via the intestinal environment: A double-blind, placebo-controlled study.

Bifidobacterium breve M-16V regulates the autonomic nervous system via the intestinal environment: A double-blind, placebo-controlled study.

Authors :
Mutoh N
Moriya M
Xu C
Kato K
Arai S
Iwabuchi N
Tanaka M
Jinghua Y
Itamura R
Sakatani K
Warisawa S
Source :
Behavioural brain research [Behav Brain Res] 2024 Mar 05; Vol. 460, pp. 114820. Date of Electronic Publication: 2023 Dec 20.
Publication Year :
2024

Abstract

We conducted a randomized controlled trial to investigate the potential of Bifidobacterium breve M-16 V to improve mood in humans. In this evaluation, we incorporated the use of near-infrared spectroscopy (NIRS), which has been used to evaluate mood states in studies with small sample sizes. Participants were given B. breve M-16 V (20 billion cells/day) for 6 weeks, and their mood state was assessed before and after ingestion. NIRS data were collected at rest and during a mental arithmetic task (under stress). Intake of B. breve M-16 V decreased the heart rate under stress and increased levels of the GABA-like substance pipecolic acid in stool samples. In addition, B. breve M-16 V improved mood and sleep scores in participants with high anxiety levels. These results suggest that B. breve M-16 V affects the metabolites of the gut microbiota and has the potential to modulate the autonomic nervous system and to improve mood and sleep.<br />Competing Interests: Declaration of Competing Interest N.M., C.X., K.K., S.A., N.I. and M.T. are employed by Morinaga Milk Industry, Co., Ltd. Y. J. had a consulting contract with Morinaga Milk Industry, Co., Ltd. M.M., R.I., K.S. and S.W. had no conflicts of interest.<br /> (Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1872-7549
Volume :
460
Database :
MEDLINE
Journal :
Behavioural brain research
Publication Type :
Academic Journal
Accession number :
38128887
Full Text :
https://doi.org/10.1016/j.bbr.2023.114820