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Ambient PM 2.5 -bound polycyclic aromatic hydrocarbons (PAHs) associated with pro-thrombotic biomarkers among young healthy adults: A 16 times repeated measurements panel study.
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The Science of the total environment [Sci Total Environ] 2024 Feb 20; Vol. 912, pp. 169433. Date of Electronic Publication: 2023 Dec 20. - Publication Year :
- 2024
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Abstract
- Studies have shown that the cardio/cerebrovascular toxicity of ambient PM <subscript>2.5</subscript> is related to its bound polycyclic aromatic hydrocarbons (PAHs). Currently, only a few studies have reported the relationship between PM <subscript>2.5</subscript> -bound PAHs and promoted blood coagulation and thrombosis, but there isn't a consistent conclusion. Therefore, we conducted a prospective panel study to investigate the association. Thirty-three young healthy adults participated in sixteen repeated visits from 2014 to 2018 in Tianjin, China. During each visit, three pro-thrombotic biomarkers: ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin motif 13), D-dimer and Myeloperoxidase (MPO) were measured. Before each visit, ambient PM <subscript>2.5</subscript> samples were daily collected for one week. Sixteen PAHs were determined using Gas Chromatography-Mass Spectrometer, and the positive matrix factorization (PMF) model was applied to identify the sources. Linear mixed-effects models were fitted to investigate the associations between PM <subscript>2.5</subscript> -bound PAHs exposure and the biomarkers. Thirteen time-metrics were defined to identify significant time points of PM <subscript>2.5</subscript> -bound PAHs' effects. We observed that the increase of PM <subscript>2.5</subscript> -bound PAHs exposure was significantly associated with reduced ADAMTS13, elevated D-dimer and MPO. At lag0, each 5.7 ng/m <superscript>3</superscript> increase in Benzo[j]fluoranthene and per 3.4 ng/m <superscript>3</superscript> increase Dibenz[a,h]anthracene could make a maximum change of -19.08 % in ADAMTS13 and 132.60 % in D-dimer. Additionally, per 16.43 ng/m <superscript>3</superscript> increase in Chrysene could lead to a maximum elevation of 32.14 % in MPO at lag4. The PM <subscript>2.5</subscript> -bound PAHs often triggered more significant changes at lag 3,4 and 6. The ambient PM <subscript>2.5</subscript> -bound PAHs originated from six sources: coal combustion (43.10 %), biomass combustion (20.77 %), diesel emission (14.78 %), gasoline emission (10.95 %), industrial emission (7.58 %), and cooking emission (2.83 %). The greatest contributors to alterations in ADAMTS13, D-dimer and MPO are industrial emission (-48.43 %), biomass combustion (470.32 %) and diesel emission (13.14 %) at lag4. Our findings indicated that short-term exposure to ambient PM <subscript>2.5</subscript> -bound PAHs can induce alterations of pro-thrombotic biomarkers among healthy adults.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2023 Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-1026
- Volume :
- 912
- Database :
- MEDLINE
- Journal :
- The Science of the total environment
- Publication Type :
- Academic Journal
- Accession number :
- 38128672
- Full Text :
- https://doi.org/10.1016/j.scitotenv.2023.169433