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Iron-Catalyzed Site- and Regioselective 1,2-Azidoamidations of 1,3-Dienes.
- Source :
-
Organic letters [Org Lett] 2024 Jan 12; Vol. 26 (1), pp. 269-273. Date of Electronic Publication: 2023 Dec 21. - Publication Year :
- 2024
-
Abstract
- The direct 1,2-azidoamidation of unsaturated precursors represents an advantageous approach for the facile synthesis of β-functionalized azides from readily available starting materials. In this paper, we describe a convenient and mild iron-catalyzed 1,2-azidoamidation of 1,3-dienes that shows excellent functional group compatibility to furnish versatile precursors to 1,2-diamine products with high levels of site, regio-, and stereoselectivity. The reaction is proposed to proceed via a single electron transfer/radical addition/C-N bond formation relay process.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 26
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 38127720
- Full Text :
- https://doi.org/10.1021/acs.orglett.3c03947