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Metronidazole-loaded polydopamine nanomedicine with antioxidant and antibacterial bioactivity for periodontitis.
- Source :
-
Nanomedicine (London, England) [Nanomedicine (Lond)] 2023 Dec; Vol. 18 (29), pp. 2143-2157. Date of Electronic Publication: 2023 Dec 21. - Publication Year :
- 2023
-
Abstract
- Aim: This study focused on treating periodontitis with bacterial infection and local over accumulation of reactive oxygen species. Materials & methods: Polydopamine nanoparticles (PDA NPs) were exploited as efficient carriers for encapsulated metronidazole (MNZ). The therapeutic efficacy and biocompatibility of PDA@MNZ NPs were investigated through both in vitro and in vivo studies. Results: The nanodrug PDA@MNZ NPs were successfully fabricated, with well-defined physicochemical characteristics. In vitro , the PDA@MNZ NPs effectively eliminated intracellular reactive oxygen species and inhibited the growth of Porphyromonas gingivalis . Moreover, the PDA@MNZ NPs exhibited synergistic therapy for periodontitisin in vivo . Conclusion: PDA@MNZ NPs were confirmed with exceptional antimicrobial and antioxidant functions, offering a promising avenue for synergistic therapy in periodontitis.
Details
- Language :
- English
- ISSN :
- 1748-6963
- Volume :
- 18
- Issue :
- 29
- Database :
- MEDLINE
- Journal :
- Nanomedicine (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 38127626
- Full Text :
- https://doi.org/10.2217/nnm-2023-0245