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Predictors of Trypanosoma cruzi PCR positivity in patients with chronic Chagas disease.
- Source :
-
Memorias do Instituto Oswaldo Cruz [Mem Inst Oswaldo Cruz] 2023 Dec 15; Vol. 118, pp. e230115. Date of Electronic Publication: 2023 Dec 15 (Print Publication: 2023). - Publication Year :
- 2023
-
Abstract
- Background: A positive Trypanosoma cruzi polymerase chain reaction (PCR) is associated with a worse prognosis in patients with chronic Chagas disease (CD).<br />Objectives: To study the association of clinical, electrocardiographic, and echocardiographic characteristics and biomarker blood levels with positive T. cruzi PCR in chronic CD.<br />Methods: This is a single-centre observational cross-sectional study. Positive T. cruzi PCR association with clinical, electrocardiographic, and echocardiographic characteristics, and biomarker blood levels were studied by logistic regression analysis. p values < 0.05 were considered significant.<br />Findings: Among 333 patients with chronic CD (56.4% men; 62 ± 10 years), T. cruzi PCR was positive in 41.1%. Stepwise multivariate logistic regression showed an independent association between positive T. cruzi PCR and diabetes mellitus {odds ratio (OR) 0.53 [95% confidence interval (CI) 0.30-0.93]; p = 0.03}, right bundle branch block [OR 1.78 (95% CI 1.09-2.89); p = 0.02], and history of trypanocidal treatment [OR 0.13 (95% CI 0.04-0.38); p = 0.0002]. Among patients with a history of trypanocidal treatment (n = 39), only four (10%) patients had a positive T. cruzi PCR.<br />Main Conclusions: Among several studied parameters, only diabetes mellitus, right bundle branch block, and history of trypanocidal treatment showed an independent association with positive T. cruzi PCR. History of trypanocidal treatment was a strong protective factor against a positive T. cruzi PCR.
- Subjects :
- Female
Humans
Male
Biomarkers
Bundle-Branch Block complications
Bundle-Branch Block drug therapy
Chronic Disease
Cross-Sectional Studies
Polymerase Chain Reaction
Middle Aged
Aged
Chagas Disease drug therapy
Diabetes Mellitus drug therapy
Trypanocidal Agents therapeutic use
Trypanosoma cruzi genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1678-8060
- Volume :
- 118
- Database :
- MEDLINE
- Journal :
- Memorias do Instituto Oswaldo Cruz
- Publication Type :
- Academic Journal
- Accession number :
- 38126526
- Full Text :
- https://doi.org/10.1590/0074-02760230115