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IgG4-related pancreatobiliary diseases could be associated with onset of pancreatobiliary cancer: A multicenter cohort study.
- Source :
-
Journal of hepato-biliary-pancreatic sciences [J Hepatobiliary Pancreat Sci] 2024 Mar; Vol. 31 (3), pp. 173-182. Date of Electronic Publication: 2023 Dec 20. - Publication Year :
- 2024
-
Abstract
- Background: The risk and prognosis of pancreatobiliary cancer and in patients with autoimmune pancreatitis (AIP) and IgG4-related sclerosing cholangitis (IgG4-SC) remain unclear. Therefore, we retrospectively investigated the risk of pancreatobiliary cancer and prognosis in patients with AIP and IgG4-SC.<br />Methods: Patients with AIP and IgG4-SC at seven centers between 1998 and 2022 were investigated. The following data were evaluated: (1) the number of cancers diagnosed and standardized incidence ratio (SIR) for pancreatobiliary and other cancers during the observational period and (2) prognosis after diagnosis of AIP and IgG4-SC using standardized mortality ratio (SMR).<br />Results: This study included 201 patients with AIP and IgG4-SC. The mean follow-up period was 5.7 years. Seven cases of pancreatic cancer were diagnosed, and the SIR was 8.11 (95% confidence interval [CI]: 7.29-9.13). Three cases of bile duct cancer were diagnosed, and the SIR was 6.89 (95% CI: 6.20-7.75). The SMR after the diagnosis of AIP and IgG4-SC in cases that developed pancreatobiliary cancer were 4.03 (95% CI: 2.83-6.99).<br />Conclusions: Patients with autoimmune pancreatitis and IgG4-SC were associated with a high risk of pancreatic and bile duct cancer. Patients with AIP and IgG4-SC have a worse prognosis when they develop pancreatobiliary cancer.<br /> (© 2023 Japanese Society of Hepato-Biliary-Pancreatic Surgery.)
- Subjects :
- Humans
Retrospective Studies
Immunoglobulin G
Diagnosis, Differential
Pancreatitis diagnosis
Autoimmune Pancreatitis complications
Autoimmune Pancreatitis diagnosis
Autoimmune Diseases diagnosis
Cholangitis, Sclerosing complications
Pancreatic Neoplasms diagnosis
Bile Duct Neoplasms diagnosis
Subjects
Details
- Language :
- English
- ISSN :
- 1868-6982
- Volume :
- 31
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of hepato-biliary-pancreatic sciences
- Publication Type :
- Academic Journal
- Accession number :
- 38124014
- Full Text :
- https://doi.org/10.1002/jhbp.1404