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Sleep breathing disorder frequency, risk factors, and treatment among adults with cystic fibrosis.
- Source :
-
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2024 Jan; Vol. 23 (1), pp. 144-149. Date of Electronic Publication: 2023 Dec 20. - Publication Year :
- 2024
-
Abstract
- Background: Our understanding of the epidemiology of sleep breathing disorders among adults with cystic fibrosis (CF) is limited. Our purpose was to describe the frequency, risk factors and treatment of sleep breathing disorders among adults with CF.<br />Methods: This was a retrospective analysis of linked data from laboratory-based diagnostic polysomnography (PSG) undertaken at St. Michael's Hospital (Toronto, Canada) and the Canadian CF Registry. Adults (≥19 years old) with CF that underwent a diagnostic PSG at St. Michael's Hospital between 2002 and 2021 were included. Sleep breathing disorder frequency, risk factors, and treatment were described, using descriptive statistics and logistic regression.<br />Results: There were 42 patients included (33.3 % women and median age at diagnostic PSG was 34.7 years). Obstructive sleep apnea [OSA] was the most commonly observed sleep breathing disorder (found in 64.3 %), followed by sustained nocturnal hypoxemia (16.7 %), and sleep hypoventilation (9.5 %). Only 41 % of individuals with an elevated total apnea-hypopnea index were receiving positive airway pressure [PAP] therapy. Corticosteroid use (either oral or inhaled) was the only factor with a significant positive association with presence of any sleep breathing disorder (odds ratio 5.00, 95 % confidence interval 1.28-22.78).<br />Conclusions: Among adults with CF, OSA occurs more commonly than previously appreciated and the majority of sleep breathing disorders were not being treated with PAP or supplemental oxygen. Management of sleep breathing disorders among adults with CF reflects a potentially important care gap, but further research is needed to determine the health impacts of treating sleep breathing disorders in CF.<br />Competing Interests: Declaration of Competing Interest AM, XM, ET, CMR, AA, ALS and NTV have no conflicts to disclose.<br /> (Copyright © 2023 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Humans
Female
Young Adult
Male
Retrospective Studies
Canada epidemiology
Sleep
Risk Factors
Cystic Fibrosis complications
Cystic Fibrosis diagnosis
Cystic Fibrosis epidemiology
Sleep Apnea, Obstructive diagnosis
Sleep Apnea, Obstructive epidemiology
Sleep Apnea, Obstructive etiology
Sleep Wake Disorders
Subjects
Details
- Language :
- English
- ISSN :
- 1873-5010
- Volume :
- 23
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
- Publication Type :
- Academic Journal
- Accession number :
- 38123381
- Full Text :
- https://doi.org/10.1016/j.jcf.2023.12.005