Back to Search
Start Over
Case Report: In Situ and Systemic Immune Response to Mucosal Leishmaniasis in an HIV-Infected Patient.
- Source :
-
The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 2023 Dec 18; Vol. 110 (2), pp. 228-233. Date of Electronic Publication: 2023 Dec 18 (Print Publication: 2024). - Publication Year :
- 2023
-
Abstract
- In situ and systemic evaluations of the immune responses of HIV-infected patients to mucosal leishmaniasis have been poorly described. We describe a recently diagnosed HIV-infected patient with mucosal leishmaniasis who was characterized by a CD4 count of 85 cells/mm3 and nasal septum destruction resulting from pruritic and ulcerated nasal mucosa with crust formation and progression over 2 years. In situ and systemic immune evaluations of T cell activation, memory, and exhaustion were conducted using cytofluorometric assays, and sequencing of the Leishmania species was performed. The immune profile of HIV-infected patient with mucosal leishmaniasis shows a mixed Th1/Th2 pattern and an activated and exhausted status.
Details
- Language :
- English
- ISSN :
- 1476-1645
- Volume :
- 110
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The American journal of tropical medicine and hygiene
- Publication Type :
- Report
- Accession number :
- 38109765
- Full Text :
- https://doi.org/10.4269/ajtmh.23-0287