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Suspecting Non-Alzheimer's Pathologies and Mixed Pathologies: A Comparative Study Between Brain Metabolism and Tau Images.
- Source :
-
Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2024; Vol. 97 (1), pp. 421-433. - Publication Year :
- 2024
-
Abstract
- Background: Alzheimer's disease (AD) pathology can be disclosed in vivo using amyloid and tau imaging, unlike non-AD neuropathologies for which no specific markers exist.<br />Objective: We aimed to compare brain hypometabolism and tauopathy to unveil non-AD pathologies.<br />Methods: Sixty-one patients presenting cognitive complaints (age 48-90), including 32 with positive AD biomarkers (52%), performed [18F]-Fluorodeoxyglucose (FDG)-PET (brain metabolism) and [18F]-MK-6240-PET (tau). We normalized these images using data from clinically normal individuals (n = 30), resulting in comparable FDG and tau z-scores. We computed between-patients correlations to evaluate regional associations. For each patient, a predominant biomarker (i.e., Hypometabolism > Tauopathy or Hypometabolism≤Tauopathy) was determined in the temporal and frontoparietal lobes. We computed within-patient correlations between tau and metabolism and investigated their associations with demographics, cognition, cardiovascular risk factors (CVRF), CSF biomarkers, and white matter hypointensities (WMH).<br />Results: We observed negative associations between tau and FDG in 37 of the 68 cortical regions-of-interest (average Pearson's r = -0.25), mainly in the temporal lobe. Thirteen patients (21%) had Hypometabolism > Tauopathy whereas twenty-five patients (41%) had Hypometabolism≤Tauopathy. Tau-predominant patients were more frequently females and had greater amyloid burden. Twenty-three patients (38%) had Hypometabolism≤Tauopathy in the temporal lobe, but Hypometabolism > Tauopathy in the frontoparietal lobe. This group was older and had higher CVRF than Tau-predominant patients. Patients with more negative associations between tau and metabolism were younger, had worse cognition, and greater amyloid and WMH burdens.<br />Conclusions: Tau-FDG comparison can help suspect non-AD pathologies in patients presenting cognitive complaints. Stronger Tau-FDG correlations are associated with younger age, worse cognition, and greater amyloid and WMH burdens.
- Subjects :
- Aged
Aged, 80 and over
Female
Humans
Amyloid metabolism
Amyloid beta-Peptides metabolism
Biomarkers metabolism
Brain diagnostic imaging
Brain metabolism
Fluorodeoxyglucose F18 metabolism
Positron-Emission Tomography methods
tau Proteins metabolism
Male
Middle Aged
Alzheimer Disease metabolism
Cognitive Dysfunction psychology
Tauopathies diagnostic imaging
Tauopathies metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1875-8908
- Volume :
- 97
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of Alzheimer's disease : JAD
- Publication Type :
- Academic Journal
- Accession number :
- 38108350
- Full Text :
- https://doi.org/10.3233/JAD-230696