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A Chemical Counterpart to the Resolution Step of Nature's Intein-Mediated Protein Splicing.
- Source :
-
ACS chemical biology [ACS Chem Biol] 2024 Jan 19; Vol. 19 (1), pp. 9-14. Date of Electronic Publication: 2023 Dec 14. - Publication Year :
- 2024
-
Abstract
- In the course of an attempted total chemical synthesis of the ant insulin-like peptide-2 (ILP2) protein molecule, specific cleavage of a backbone peptide bond in a branched ester-linked polypeptide chain with concomitant peptide splicing was observed. The side reaction was investigated in model compounds. Here, we postulate a chemical mechanism for this novel polypeptide backbone cleavage reaction as a chemical counterpart to the resolution step of biochemical intein-mediated protein splicing.
- Subjects :
- Proteins
Peptides chemistry
RNA Splicing
Inteins
Protein Splicing
Subjects
Details
- Language :
- English
- ISSN :
- 1554-8937
- Volume :
- 19
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- ACS chemical biology
- Publication Type :
- Academic Journal
- Accession number :
- 38096499
- Full Text :
- https://doi.org/10.1021/acschembio.3c00590