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Dual-target inhibitors based on COX-2: a review from medicinal chemistry perspectives.
- Source :
-
Future medicinal chemistry [Future Med Chem] 2023 Dec; Vol. 15 (23), pp. 2209-2233. Date of Electronic Publication: 2023 Dec 14. - Publication Year :
- 2023
-
Abstract
- Inhibitors of COX-2 constitute a class of anti-inflammatory analgesics, showing potential against certain types of cancer. However, such inhibitors are associated with cardiovascular toxicity. Moreover, although single-target molecules possess specificity for particular targets, they often lead to poor safety, low efficacy and drug resistance due to compensatory mechanisms. A new generation of dual-target drugs that simultaneously inhibit COX-2 and another target is showing strong potential to treat cancer or reduce adverse cardiac effects. The present perspective focuses on the structure and functions of COX-2, and its role as a therapeutic target. It also explores the current state and future possibilities for dual-target strategies from a medicinal chemistry perspective.
- Subjects :
- Humans
Antineoplastic Agents adverse effects
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Antineoplastic Agents therapeutic use
Models, Molecular
Protein Structure, Tertiary
Structure-Activity Relationship
Neoplasms drug therapy
Cyclooxygenase 2 chemistry
Cyclooxygenase 2 metabolism
Cyclooxygenase 2 Inhibitors adverse effects
Cyclooxygenase 2 Inhibitors chemistry
Cyclooxygenase 2 Inhibitors pharmacology
Cyclooxygenase 2 Inhibitors therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1756-8927
- Volume :
- 15
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- Future medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 38095081
- Full Text :
- https://doi.org/10.4155/fmc-2023-0192