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Apelin and the gut microbiome: Potential interaction in human MASLD.
- Source :
-
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2024 Jun; Vol. 56 (6), pp. 932-940. Date of Electronic Publication: 2023 Dec 11. - Publication Year :
- 2024
-
Abstract
- Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease with increasing numbers worldwide. Adipokines like apelin (APLN) can act as key players in the complex pathophysiology of MASLD.<br />Aims: Investigating the role of APLN in MASLD.<br />Methods: Fecal and blood samples were collected in a MASLD cohort and healthy controls (HC). MASLD patients with liver fibrosis and MASLD-associated hepatocellular carcinoma (HCC) were included into the study. Systemic concentration of Apelin, Apelin receptor (APLNR) and circulating cytokines were measured in serum samples.<br />Results: Apelin concentration correlated with the Fib-4 score and was elevated in MASLD patients (mild fibrosis, mF (Fib-4 <3.25) and severe fibrosis, sF (Fib-4 >3.25)) as well as in MASLD-associated HCC patients compared to HC. In accordance APLNR and circulating cytokines were also elevated in mF and sF. In contrast apelin levels were negatively associated with liver survival at three and five years. Changes in taxa composition at phylum level showed an increase of Enterobactericae, Prevotellaceae and Lactobacillaceae in patients with sF compared to mF. We could also observe an association between apelin concentrations and bacterial lineages (phyla).<br />Conclusions: Circulating apelin is associated with liver fibrosis and HCC. In addition, there might exist an interaction between systemic apelin and the gut microbiome.<br />Competing Interests: Conflict of interest None.<br /> (Copyright © 2023 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Humans
Male
Female
Middle Aged
Case-Control Studies
Aged
Liver Neoplasms microbiology
Apelin Receptors metabolism
Cytokines blood
Feces microbiology
Feces chemistry
Adult
Apelin blood
Gastrointestinal Microbiome
Carcinoma, Hepatocellular microbiology
Carcinoma, Hepatocellular blood
Liver Cirrhosis microbiology
Liver Cirrhosis blood
Subjects
Details
- Language :
- English
- ISSN :
- 1878-3562
- Volume :
- 56
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
- Publication Type :
- Academic Journal
- Accession number :
- 38087672
- Full Text :
- https://doi.org/10.1016/j.dld.2023.11.023