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Prevalence of pulmonary hypertension in obstructive sleep apnea and its relation to disease severity.
- Source :
-
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine [J Clin Sleep Med] 2024 May 01; Vol. 20 (5), pp. 675-680. - Publication Year :
- 2024
-
Abstract
- Study Objectives: The purpose of this study is to examine the prevalence of pulmonary hypertension (PHTN) in children with obstructive sleep apnea (OSA) using echocardiographic (ECHO) parameters and to examine ECHO findings as they relate to severity of OSA.<br />Methods: A retrospective cohort study of patients with OSA undergoing polysomnogram and ECHO within 30 days of each other, between January 1, 2015, and December 31, 2020, was performed, excluding cardiac disease. ECHO evidence of PHTN was defined as ≥ 2 of the following: tricuspid regurgitation velocity > 3.0 m/s, pulmonary acceleration/ejection time ratio < 0.3, left ventricular eccentricity index > 1.5, and right ventricular dysfunction or abnormal geometry. ECHO parameters were compared to OSA severity using obstructive apnea-hypopnea index, percent of time with oxygen saturation < 90%, and percent of time with end-tidal carbon dioxide > 50 mmHg. Odds ratios were calculated for each comorbidity to evaluate for risk factors.<br />Results: Of 509 patients, 4.3% were found to have echocardiographic evidence of PHTN. Neither obstructive apnea-hypopnea index severity nor worsening hypoxemia or hypercarbia correlated with worsening ECHO parameters. Comorbidities including bronchopulmonary dysplasia (odds ratio, 5.22, 2.01-13.53), prematurity (odds ratio, 3.10, 1.28-7.47), and autism (odds ratio, 3.69, 1.01-13.49) were associated with increased odds of PHTN.<br />Conclusions: Significant echocardiographic evidence of PHTN was seen in 4.3% of children with OSA. ECHO findings of PHTN did not correlate with polysomnogram parameters. Comorbidities, particularly bronchopulmonary dysplasia, prematurity, and autism, appear to be a risk factor for developing PHTN in patients with OSA.<br />Citation: Milligan I, Shaw AK, Leu R, Kanaan U, Michelfelder E. Prevalence of pulmonary hypertension in obstructive sleep apnea and its relation to disease severity. J Clin Sleep Med . 2024;20(5):675-680.<br /> (© 2024 American Academy of Sleep Medicine.)
- Subjects :
- Humans
Retrospective Studies
Female
Male
Prevalence
Child
Child, Preschool
Risk Factors
Cohort Studies
Comorbidity
Adolescent
Sleep Apnea, Obstructive epidemiology
Sleep Apnea, Obstructive complications
Hypertension, Pulmonary epidemiology
Hypertension, Pulmonary complications
Hypertension, Pulmonary physiopathology
Severity of Illness Index
Echocardiography statistics & numerical data
Echocardiography methods
Polysomnography
Subjects
Details
- Language :
- English
- ISSN :
- 1550-9397
- Volume :
- 20
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 38078676
- Full Text :
- https://doi.org/10.5664/jcsm.10952