A new sacculatane diterpenoid and a new oplopanone sesquiterpenoid from Porella perrottetiana (Mont.) Trevis. collected in Sapa, Vietnam.

From the n -hexane extract of the liverwort Porella perrottetiana collected in Sapa (North Vietnam), a new sacculatane diterpenoid (perrottetianal E ( 1 )) and a new oplopanone sesquiterpenoid ((+)-oplopanone C ( 2 )), along with two known sesquiterpenes ( 3 and 4 ), and two known phaeophytins ( 5 and 6 ) have been isolated. Their structures were elucidated based on the analysis of NMR spectroscopic data, in combination with HR-ESIMS and the reported data. Compounds 1-4 were evaluated for their cytotoxic activities against three cancer cell lines: KB (human carcinoma in the mouth), HepG2 (human hepatocellular carcinoma), and A549 (human lung carcinoma).