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Impact of Bariatric Surgery on Subtilisin/Kexin Type 9 (PCSK9) Gene Expression and Inflammation in the Adipose Tissue of Obese Diabetic Rats.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2023 Nov 30; Vol. 24 (23). Date of Electronic Publication: 2023 Nov 30. - Publication Year :
- 2023
-
Abstract
- Bariatric surgery improves dyslipidaemia and reduces body weight, but it remains unclear how bariatric surgery modulates gene expression in fat cells to influence the proprotein convertase subtilisin/kexin type 9 (PCSK-9) and low-density lipoprotein receptor (LDLR) gene expression. The expression of the PCSK9/LDLR/tumor necrosis factor-alpha (TNFα) gene in adipose tissue was measured in two groups of Zucker Diabetic Sprague Dawley (ZDSD) rats after Roux-en-Y gastric bypass (RYGB) surgery or 'SHAM' operation. There was lower PCSK9 ( p = 0.02) and higher LDLR gene expression ( p = 0.02) in adipose tissue in rats after RYGB. Weight change did not correlate with PCSK9 gene expression (r = -0.5, p = 0.08) or TNFα gene expression (r = -0.4, p = 0.1). TNFα gene expression was positively correlated with PCSK9 gene expression (r = 0.7, p = 0.001) but not correlated with LDLR expression (r = -0.3, p = 0.3). Circulating triglyceride levels were lower in RYGB compared to the SHAM group (1.1 (0.8-1.4) vs. 1.5 (1.0-4.2), p = 0.038) mmol/L with no difference in cholesterol levels. LDLR gene expression was increased post-bariatric surgery with the potential to reduce the number of circulating LDL particles. PCSK9 gene expression and TNFα gene expression were positively correlated after RYGB in ZDSD rats, suggesting that the modulation of pro-inflammatory pathways in adipose tissue after RYGB may partly relate to PCSK9 and LDLR gene expression.
- Subjects :
- Animals
Rats
Adipose Tissue metabolism
Gene Expression
Inflammation genetics
Obesity genetics
Obesity surgery
Proprotein Convertase 9 genetics
Proprotein Convertases genetics
Rats, Sprague-Dawley
Rats, Zucker
Receptors, LDL genetics
Receptors, LDL metabolism
Serine Endopeptidases metabolism
Subtilisin genetics
Tumor Necrosis Factor-alpha genetics
Bariatric Surgery
Diabetes Mellitus, Experimental genetics
Diabetes Mellitus, Experimental surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 24
- Issue :
- 23
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 38069302
- Full Text :
- https://doi.org/10.3390/ijms242316978