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D-Dimer Trends Predict Recurrent Stroke in Patients with Cancer-Related Hypercoagulability.
- Source :
-
Cerebrovascular diseases extra [Cerebrovasc Dis Extra] 2024; Vol. 14 (1), pp. 9-15. Date of Electronic Publication: 2023 Dec 07. - Publication Year :
- 2024
-
Abstract
- Introduction: In patients with cancer-associated hypercoagulability (CAH)-related stroke, D-dimer trends after anticoagulant therapy may offer a biomarker of treatment efficacy. The purpose of this study was to clarify the association between D-dimer trends and recurrent stroke after anticoagulant therapy in patients with CAH-related stroke.<br />Methods: We performed retrospective cohort study of consecutive patients with CAH-related stroke at two stroke centers from 2011 to 2020. The ratio of posttreatment to pretreatment D-dimer levels (post/pre ratio) was used as an indicator of D-dimer trends after anticoagulant therapy. Fine-Gray models were used to evaluate the association between post/pre ratio and recurrent stroke.<br />Results: Among 360 acute ischemic stroke patients with active cancer, 73 patients with CAH-related stroke were included in this study. Recurrent stroke occurred in 13 patients (18%) during a median follow-up time of 28 days (interquartile range, 11-65 days). Multivariate analysis revealed that high post/pre ratio was independently associated with recurrent stroke (per 0.1 increase: hazard ratio 2.20, 95% confidence interval 1.61-3.01, p = 0.012).<br />Conclusion: D-dimer levels after anticoagulant therapy were associated with recurrent stroke in CAH-related stroke patients. Patients with neutral trends in high D-dimer levels after anticoagulant therapy were at high risk of recurrent stroke.<br /> (© 2023 The Author(s). Published by S. Karger AG, Basel.)
- Subjects :
- Humans
Retrospective Studies
Risk Factors
Fibrin Fibrinogen Degradation Products analysis
Cerebral Infarction
Anticoagulants adverse effects
Ischemic Stroke complications
Stroke diagnosis
Stroke epidemiology
Stroke complications
Thrombophilia diagnosis
Thrombophilia drug therapy
Thrombophilia complications
Neoplasms complications
Neoplasms diagnosis
Neoplasms drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1664-5456
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Cerebrovascular diseases extra
- Publication Type :
- Academic Journal
- Accession number :
- 38061347
- Full Text :
- https://doi.org/10.1159/000535644