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Clinical relevance of exosome-derived microRNAs in Ovarian Cancer: Looking for new tumor biological fingerprints.
- Source :
-
Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2024 Jan; Vol. 193, pp. 104220. Date of Electronic Publication: 2023 Nov 29. - Publication Year :
- 2024
-
Abstract
- Specific tumor-derived extracellular vesicles, called exosomes, are considered as potential key players in cross-talk between immune system and tumor microenvironment in several solid tumors. Different studies highlighted the clinical relevance of exosomes in ovarian cancer (OC) for their role in early diagnosis, prognosis, chemoresistance, targeted therapy. The exosomes are nanosize vesicles carrying lipids, proteins, and nucleic acids. In particular, exosomes shuttle a wide spectrum of microRNAs (miRNAs) able to induce phenotypic reprogramming of target cells, contributing to tumor progression. In this review, we will discuss the promising role of miRNAs shuttled by exosomes, called exosomal miRNAs (exo-miRNAs), as potential biomarkers for early detection, tumour progression and metastasis, prognosis, and response to therapy in OC women, in order to search for new potential biological fingerprints able to better characterize the evolution of this malignancy and provide a clinically relevant non-invasive approach useful for adopting, in future, personalized therapeutic strategies.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2023. Published by Elsevier B.V.)
- Subjects :
- Humans
Female
Clinical Relevance
Biomarkers, Tumor genetics
Biomarkers, Tumor metabolism
Tumor Microenvironment genetics
MicroRNAs genetics
Exosomes genetics
Exosomes metabolism
Ovarian Neoplasms diagnosis
Ovarian Neoplasms genetics
Ovarian Neoplasms therapy
Extracellular Vesicles metabolism
Extracellular Vesicles pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0461
- Volume :
- 193
- Database :
- MEDLINE
- Journal :
- Critical reviews in oncology/hematology
- Publication Type :
- Academic Journal
- Accession number :
- 38036154
- Full Text :
- https://doi.org/10.1016/j.critrevonc.2023.104220