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Thirteen new peptaibols with antimicrobial activities from Trichoderma sp.
- Source :
-
Chinese journal of natural medicines [Chin J Nat Med] 2023 Nov; Vol. 21 (11), pp. 868-880. - Publication Year :
- 2023
-
Abstract
- From the fungus Trichoderma sp., we isolated seven novel 18-residue peptaibols, neoatroviridins E-K (1-7), and six new 14-residue peptaibols, harzianins NPDG J-O (8-13). Additionally, four previously characterized 18-residue peptaibols neoatroviridins A-D (14-17) were also identified. The structural configurations of the newly identified peptaibols (1-13) were determined by comprehensive nuclear magnetic resonance (NMR) and high-resolution electrospray ionization tandem mass spectrometry (HR-ESI-MS/MS) data. Their absolute configurations were further determined using Marfey's method. Notably, compounds 12 and 13 represent the first 14-residue peptaibols containing an acidic amino acid residue. In antimicrobial assessments, all 18-residue peptaibols (1-7, 14-17) exhibited moderate inhibitory activities against Staphylococcus aureus 209P, with minimum inhibitory concentration (MIC) values ranging from 8-32 μg·mL <superscript>-1</superscript> . Moreover, compound 9 exhibited moderate inhibitory effect on Candida albicans FIM709, with a MIC value of 16 μg·mL <superscript>-1</superscript> .<br /> (Copyright © 2023 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1875-5364
- Volume :
- 21
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Chinese journal of natural medicines
- Publication Type :
- Academic Journal
- Accession number :
- 38035942
- Full Text :
- https://doi.org/10.1016/S1875-5364(23)60499-6