Genetic Polymorphisms Involved in Bladder Cancer: A Global Review.

Authors :: Kourie HR
Zouein J
Succar B
Mardirossian A
Ahmadieh N
Chouery E
Mehawej C
Jalkh N
Kattan J
Nemr E
Source :: Oncology reviews [Oncol Rev] 2023 Nov 06; Vol. 17, pp. 10603. Date of Electronic Publication: 2023 Nov 06 (Print Publication: 2023).
Publication Year :: 2023
Abstract: Bladder cancer (BC) has been associated with genetic susceptibility. Single peptide polymorphisms (SNPs) can modulate BC susceptibility. A literature search was performed covering the period between January 2000 and October 2020. Overall, 334 articles were selected, reporting 455 SNPs located in 244 genes. The selected 455 SNPs were further investigated. All SNPs that were associated with smoking and environmental exposure were excluded from this study. A total of 197 genes and 343 SNPs were found to be associated with BC, among which 177 genes and 291 SNPs had congruent results across all available studies. These genes and SNPs were classified into eight different categories according to their function.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2023 Kourie, Zouein, Succar, Mardirossian, Ahmadieh, Chouery, Mehawej, Jalkh, kattan and Nemr.)