Back to Search
Start Over
Early Outcomes of an Artificial Endothelial Replacement Membrane Implantation After Failed Repeat Endothelial Keratoplasty.
- Source :
-
Cornea [Cornea] 2024 Sep 01; Vol. 43 (9), pp. 1088-1094. Date of Electronic Publication: 2023 Nov 22. - Publication Year :
- 2024
-
Abstract
- Purpose: The purpose of this study was to report the outcomes of a novel artificial endothelial replacement membrane implant for treating corneal edema after failed repeat endothelial keratoplasty (EK).<br />Design: This was a retrospective interventional case series.<br />Methods: Patients with chronic corneal edema underwent removal of the EK graft and implantation of an artificial endothelial replacement membrane (EndoArt, EyeYon Medical, Israel) several months after 2 or more Descemet stripping endothelial keratoplasty procedures. The implant was secured to the posterior corneal surface using an air-gas bubble. Outcome measures included corrected distance visual acuity (logMAR), central corneal thickness, device-related complications, and ocular discomfort.<br />Results: Five eyes of 5 patients underwent EndoArt implantation. Six months after surgery, the synthetic endothelial replacement membrane was well-centered and adherent to the posterior corneal surface, with improvement in central corneal transparency in all patients. Corrected distance visual acuity increased from mean 1.26 ± 0.25 (logMAR) preoperatively to 0.74 ± 0.44 (logMAR) postoperatively ( P = 0.06). Central corneal thickness significantly decreased from a mean of 805 ± 135 μm (excluding the EK graft) preoperatively to 588 ± 60 μm (excluding the EndoArt) postoperatively ( P = 0.015). No severe device-related complications developed after surgery, although most patients required more than 1 air-gas bubble injection to achieve complete implant adhesion. All patients experienced preoperative reduction in subjective ocular pain.<br />Conclusions: Synthetic endothelial replacement membrane implantation improves central corneal transparency and visual acuity in patients with failed EK and guarded prognosis for repeat keratoplasty. No significant implant-related adverse events occurred after surgery.<br />Competing Interests: The authors have no funding or conflicts of interest to disclose.<br /> (Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc.)
- Subjects :
- Humans
Retrospective Studies
Male
Female
Aged
Middle Aged
Membranes, Artificial
Treatment Outcome
Aged, 80 and over
Visual Acuity physiology
Descemet Stripping Endothelial Keratoplasty methods
Endothelium, Corneal transplantation
Endothelium, Corneal pathology
Reoperation
Corneal Edema surgery
Subjects
Details
- Language :
- English
- ISSN :
- 1536-4798
- Volume :
- 43
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Cornea
- Publication Type :
- Academic Journal
- Accession number :
- 38015948
- Full Text :
- https://doi.org/10.1097/ICO.0000000000003433