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Liposome-based vaccines for minimally or noninvasive administration: an update on current advancements.
- Source :
-
Expert opinion on drug delivery [Expert Opin Drug Deliv] 2023 Jul-Dec; Vol. 20 (11), pp. 1573-1593. Date of Electronic Publication: 2023 Dec 20. - Publication Year :
- 2023
-
Abstract
- Introduction: Vaccination requires innovation to provide effective protection. Traditional vaccines have several drawbacks, which can be overcome with advanced technologies and different administration routes. Over the past 10 years, a significant amount of research has focussed on the delivery of antigens into liposomes due to their dual role as antigen-carrying systems and vaccine adjuvants able to increase the immunogenicity of the carried antigen.<br />Areas Covered: This review encompasses the progress made over the last 10 years with liposome-based vaccines designed for minimally or noninvasive administration, filling the gaps in previous reviews and providing insights on composition, administration routes, results achieved, and Technology Readiness Level of the most recent formulations.<br />Expert Opinion: Liposome-based vaccines administered through minimally or noninvasive routes are expected to improve efficacy and complacency of vaccination programs. However, the translation from lab-scale production to large-scale production and collaborations with hospitals, research centers, and companies are needed to allow new products to enter the market and improve the vaccination programs in the future.
- Subjects :
- Vaccination methods
Antigens
Adjuvants, Immunologic
Liposomes
Vaccines
Subjects
Details
- Language :
- English
- ISSN :
- 1744-7593
- Volume :
- 20
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Expert opinion on drug delivery
- Publication Type :
- Academic Journal
- Accession number :
- 38015659
- Full Text :
- https://doi.org/10.1080/17425247.2023.2288856