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Age-dependent changes in the gut microbiota and serum metabolome correlate with renal function and human aging.

Authors :
Sun L
Li Z
Hu C
Ding J
Zhou Q
Pang G
Wu Z
Yang R
Li S
Li J
Cai J
Sun Y
Li R
Zhen H
Sun S
Zhang J
Fang M
Chen Z
Lv Y
Cao Q
Sun Y
Gong R
Huang Z
Duan Y
Liu H
Dong J
Li J
Ruan J
Lu H
He B
Li N
Li T
Xue W
Li Y
Shen J
Yang F
Zhao C
Liang Q
Zhang M
Chen C
Gong H
Hou Y
Wang J
Zhang Y
Yang H
Zhu S
Xiao L
Jin Z
Guo H
Zhao P
Brix S
Xu X
Jia H
Kristiansen K
Yang Z
Nie C
Source :
Aging cell [Aging Cell] 2023 Dec; Vol. 22 (12), pp. e14028. Date of Electronic Publication: 2023 Nov 27.
Publication Year :
2023

Abstract

Human aging is invariably accompanied by a decline in renal function, a process potentially exacerbated by uremic toxins originating from gut microbes. Based on a registered household Chinese Guangxi longevity cohort (n = 151), we conducted comprehensive profiling of the gut microbiota and serum metabolome of individuals from 22 to 111 years of age and validated the findings in two independent East Asian aging cohorts (Japan aging cohort n = 330, Yunnan aging cohort n = 80), identifying unique age-dependent differences in the microbiota and serum metabolome. We discovered that the influence of the gut microbiota on serum metabolites intensifies with advancing age. Furthermore, mediation analyses unveiled putative causal relationships between the gut microbiota (Escherichia coli, Odoribacter splanchnicus, and Desulfovibrio piger) and serum metabolite markers related to impaired renal function (p-cresol, N-phenylacetylglutamine, 2-oxindole, and 4-aminohippuric acid) and aging. The fecal microbiota transplantation experiment demonstrated that the feces of elderly individuals could influence markers related to impaired renal function in the serum. Our findings reveal novel links between age-dependent alterations in the gut microbiota and serum metabolite markers of impaired renal function, providing novel insights into the effects of microbiota-metabolite interplay on renal function and healthy aging.<br /> (© 2023 The Authors. Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.)

Details

Language :
English
ISSN :
1474-9726
Volume :
22
Issue :
12
Database :
MEDLINE
Journal :
Aging cell
Publication Type :
Academic Journal
Accession number :
38015106
Full Text :
https://doi.org/10.1111/acel.14028