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Isolated rapid eye movement sleep behaviour disorder (iRBD) in the Island Study Linking Ageing and Neurodegenerative Disease (ISLAND) Sleep Study: protocol and baseline characteristics.
- Source :
-
Journal of sleep research [J Sleep Res] 2024 May; Vol. 33 (3), pp. e14109. Date of Electronic Publication: 2023 Nov 28. - Publication Year :
- 2024
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Abstract
- Isolated rapid eye movement (REM) sleep behaviour disorder (iRBD) is a sleep disorder that is characterised by dream enactment episodes during REM sleep. It is the strongest known predictor of α-synuclein-related neurodegenerative disease (αNDD), such that >80% of people with iRBD will eventually develop Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy in later life. More research is needed to understand the trajectory of phenoconversion to each αNDD. Only five 'gold standard' prevalence studies of iRBD in older adults have been undertaken previously, with estimates ranging from 0.74% to 2.01%. The diagnostic recommendations for video-polysomnography (vPSG) to confirm iRBD makes prevalence studies challenging, as vPSG is often unavailable to large cohorts. In Australia, there have been no iRBD prevalence studies, and little is known about the cognitive and motor profiles of Australian people with iRBD. The Island Study Linking Ageing and Neurodegenerative Disease (ISLAND) Sleep Study will investigate the prevalence of iRBD in Tasmania, an island state of Australia, using validated questionnaires and home-based vPSG. It will also explore several cognitive, motor, olfactory, autonomic, visual, tactile, and sleep profiles in people with iRBD to better understand which characteristics influence the progression of iRBD to αNDD. This paper details the ISLAND Sleep Study protocol and presents preliminary baseline results.<br /> (© 2023 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society.)
- Subjects :
- Humans
Male
Aged
Female
Prevalence
Australia epidemiology
Middle Aged
Surveys and Questionnaires
REM Sleep Behavior Disorder physiopathology
REM Sleep Behavior Disorder epidemiology
Neurodegenerative Diseases physiopathology
Neurodegenerative Diseases epidemiology
Polysomnography
Aging physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1365-2869
- Volume :
- 33
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of sleep research
- Publication Type :
- Academic Journal
- Accession number :
- 38014898
- Full Text :
- https://doi.org/10.1111/jsr.14109