Automated sulfur-[ 18 F]fluoride exchange radiolabelling of a prostate specific membrane antigen (PSMA) targeted ligand using the GE FASTlab™ cassette-based platform.

Authors :: Yang Z
Barnes C
Domarkas J
Koch-Paszkowski J
Wright J
Amgheib A
Renard I
Fu R
Archibald S
Aboagye EO
Allott L
Source :: Reaction chemistry & engineering [React Chem Eng] 2023 Aug 21; Vol. 8 (10), pp. 2403-2407. Date of Electronic Publication: 2023 Aug 21 (Print Publication: 2023).
Publication Year :: 2023
Abstract: Sulfur-[ <superscript>18</superscript> F]fluoride exchange radiochemistry is a rapid and convenient method for incorporating fluorine-18 into biologically active molecules. We report a fully automated radiolabelling procedure for the synthesis of a [ <superscript>18</superscript> F]SO <subscript>3</subscript> F-bearing prostate specific membrane antigen (PSMA) targeted ligand ([ <superscript>18</superscript> F]5) using the GE FASTLab™ cassette-based platform in a 25.0 ± 2.6% radiochemical yield (decay corrected). Uptake in vitro and in vivo correlated with PSMA expression, and the radioligand exhibited favourable biodistribution and pharmacokinetic profiles.<br />Competing Interests: There are no conflicts to declare.<br /> (This journal is © The Royal Society of Chemistry.)

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