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Biological Evaluation of Isosteric Applicability of 1,3-Substituted Cuneanes as m-Substituted Benzenes Enabled by Selective Isomerization of 1,4-Substituted Cubanes.
- Source :
-
Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Feb 21; Vol. 30 (11), pp. e202303548. Date of Electronic Publication: 2024 Jan 11. - Publication Year :
- 2024
-
Abstract
- We herein evaluate a biological applicability of 1,3-substituted cuneanes as an isostere of m-substituted benzenes based on its structural similarity. An investigation of a method to obtain 1,3-substituted cuneanes by selective isomerization of 1,4-substituted cubanes enables this attempt by giving a key synthetic step to obtain a cuneane analogs of pharmaceuticals having m-substituted benzene moiety. Biological evaluation of the synthesized analogs and in silico study of the obtained result revealed a potential usage of cuneane skeleton in medicinal chemistry.<br /> (© 2023 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.)
- Subjects :
- Isomerism
Benzene chemistry
Benzene Derivatives chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1521-3765
- Volume :
- 30
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Chemistry (Weinheim an der Bergstrasse, Germany)
- Publication Type :
- Academic Journal
- Accession number :
- 38012076
- Full Text :
- https://doi.org/10.1002/chem.202303548