Back to Search
Start Over
Inability of the BCG vaccine to protect mice of the H2 f haplotype at advanced stages of TB infection is associated with defective CD4 + T-cell activation in spleen.
- Source :
-
Tuberculosis (Edinburgh, Scotland) [Tuberculosis (Edinb)] 2023 Dec; Vol. 143, pp. 102429. Date of Electronic Publication: 2023 Nov 10. - Publication Year :
- 2023
-
Abstract
- We performed studies in B10.M H2-congenic mouse strain whose H2 <superscript>f</superscript> haplotype is associated with defective BCG vaccination efficacy against TB challenge. No difference in mortality dynamics between BCG-vaccinated and primarily infected B10.M mice was observed, whereas in B10 (H2 <superscript>b</superscript> ) congenic mice BCG vaccination significantly prolonged survival. At the early stages of infection, vaccinated mice of both strains controlled mycobacterial multiplication in lungs and draining lymph nodes better than non-vaccinated, however, in B10.M spleens no vaccination effect was evident. More activated cells expressing the CD4 <superscript>+</superscript> CD44 <superscript>+</superscript> CD62L <superscript>-</superscript> phenotype resided in spleens of vaccinated B10 compared to B10.M mice. Our results suggest that inability of BCG vaccination to prolong survival of TB-infected B10.M mice may be associated with defective response to disseminated rather than primary infection.<br />Competing Interests: Declaration of competing interest The authors report no conflict of interests.<br /> (Copyright © 2023 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1873-281X
- Volume :
- 143
- Database :
- MEDLINE
- Journal :
- Tuberculosis (Edinburgh, Scotland)
- Publication Type :
- Academic Journal
- Accession number :
- 38011759
- Full Text :
- https://doi.org/10.1016/j.tube.2023.102429