Preparation of [ 68 Ga]GaCl 3 Using a Cyclotron.

Recent developments in ⁶⁸ Ga-radiopharmaceuticals, including a number of regulatory approvals for clinical use, has created a hitherto unprecedented demand for ⁶⁸ Ga. Reliable access to enough ⁶⁸ Ga to meet growing clinical demand using only ⁶⁸ Ge/ ⁶⁸ Ga generators has been problematic in recent years. To address this challenge, we have optimized the direct production of ⁶⁸ Ga on a cyclotron via the ⁶⁸ Zn(p,n) ⁶⁸ Ga reaction using a liquid target. This protocol describes the cyclotron-based production of [ ⁶⁸ Ga]GaCl ₃ implemented at the University of Michigan using a liquid target on GE PETtrace instrumentation. The protocol provides 56 ± 4 mCi (n = 3) of [ ⁶⁸ Ga]GaCl ₃ that meets the necessary quality control criteria to use for the preparation of ⁶⁸ Ga-radiopharmaceuticals for human use.
(© 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)